Grosso Sanese originates in a vineyard covering about two hectares next to the estate headquarters. The fairly compact lime-based soil is composed mainly of alberese and galestro. The vines are pruned according to the spurred cordon method, leaving a maximum of six buds.

Production is limited to 5,000 to 6,000 liters per hectare (2.5 acres), for a total production of about 10,000 bottles per year. Fermentation takes place in 5,000-liter oak barrels. The wine is refined in barriques made of Alliers oak, thirty percent of which are replaced each year. Here it stays for eighteen months, before the final blending and bottling. The wine then ages in the bottle for another six months before being released for sale.